Masterclass: Autoimmunity in neuropsychiatric disorders
June 14th, 2017
Maastricht University, The Netherlands
Little is known about the etiology of psychiatric disorders, including schizophrenia, bipolar disorder and psychosis, but patients have been shown to have immunological abnormalities. The identification of autoantibodies targeting the N-methyl-D-aspartate receptor (NMDA-R), which causes neurological and psychiatric symptoms, has reinvigorated the hypothesis that other patient subgroups may also suffer from an underlying autoimmune condition. Recently NMDA receptor autoantibodies have been cloned and shown to cause neuronal surface receptor downregulation and subsequent impairment of NMDAR-mediated currents. In psychotic patients, intrathecal immunoglobulin synthesis, elevated white cell counts, albumin quotient and high prevalence of CSF and autoantibody abnormalities have been observed in a subgroup of patients. In the same cohort, the autoantibodies of the CSF have been found in 3.2 % of the psychotic patients to target neuronal surface antigens. Next research goals should focus on discovering undiagnosed autoimmune cases, the identification of the antigens “membrane proteins and ion channels” targeted by the autoantibodies and to understand how the autoantibodies can cause neuropsychiatric symptoms.
Registration: Maximum of 60 participants | Registration deadline: June 1st, 2017
Registration via this link: http://www.euronschool.eu/page/145/Online_registration/
After registration you will get a link to the online payment platform. Registration is definitive after payment. For Maastricht participants an internal budget number is required.
This workshop qualifies for 0.5 European credits.